Systematic Review of Treatment for Amphetamine-Related Disorders

About two thirds of the 1,280 participants in the Oregon study are homeless; none of them were in treatment when they joined the program, said Dr. Todd P. Korthuis, the study’s principal investigator. He eventually got on methadone, a medication approved by the Food and Drug Administration to treat opioid addiction. But there’s no FDA-approved medication to treat addiction to stimulants like cocaine and methamphetamines. Amphetamine-related psychiatric disorders can occur with acute or chronic use. Acute amphetamine use with resultant psychosis can present like a sympathomimetic toxidrome.

Amphetamine Addiction Treatment

Our substance abuse treatment directory helps people find the treatment they need to overcome addiction. With our easy-to-use and extensive directory, people with addictions or their loved ones can easily search for treatment at a substance use disorder recovery center near them. Our reviewers are experts in their medical fields who vet all content with the latest research, medical findings, and best practices in substance abuse and mental health care.

  • Users of amphetamines are also twice as likely to need long-term treatment than users of other drugs (17% versus 8%).
  • These findings demonstrate the efficacy of the two treatments as well as patient engagement in the treatment.
  • A person can find it hard to stop taking a substance, which usually implies that they are physically dependent on the substance.

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  • Populations under-represented in the literature must also be addressed in future research.
  • GABAergic (blue) interneurons within the ventral tegmental area regulate the activity of dopaminergic neurons projecting to the nucleus accumbens.
  • According to this rationale, the neurobiology of the amphetamine withdrawal syndrome and its relief would be related to the cumulative effects of repeated exposure of neurons to high dose amphetamines (Meredith 2005).
  • It teaches its users skills that help to achieve abstinence from substance abuse and to increase retention to outpatient programs.
  • In the US, 0.7% of the population aged 12 and older, or 1.9 million people, reported the use of METH.

Although a random effect model can be applied for the synthesis of a group of data with significant heterogeneity, the results obtained by the synthesis of this group of data have to be interpreted with great caution. In the original review, reports identified by the electronic searches were assessed for relevance. Two reviewers (MS & NJ) independently inspected all study citations identified by the electronic searches and full reports of the studies of agreed relevance were obtained. Where disputes arose the full reports were acquired for more detailed scrutiny.

1. Methamphetamine Use Disorder and Methamphetamine-induced Disorders

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In total, 39 (90.7%) were placebo controlled, while the remaining four studies (9.3%) were designed with a treatment-as-usual or alternate treatment arm as the control [36, 49, 61, 66]. Extra-medical use of AMPH and MA is usually at higher doses than those prescribed orally, and through routes of administration that result in more rapid onset (inhaled, injected intravenously, intra-nasal, per-vaginal, and per-rectal). Extra-medical consumption of amphetamines may be for enjoyment and/or for performance enhancement (such as for night-shift workers to enable longer working hours) [5]. A private company founded in 2016, DynamiCare rode a wave of venture capital funding during the pandemic for remote health treatments.

How is amphetamine dependence treated?

Recovery means different things to different people, according to their experiences, belief systems, culture, identity, and method of recovery. If a person suspects that they may have a drug misuse problem, then they should consult a medical professional. It is important for people to remember Amphetamine Addiction that they do not need to feel embarrassed about seeking help. An individual’s brain chemistry changes during regular misuse of a substance or activity. The brain’s reward circuit changes, reducing a person’s ability to exercise self-control and leading to strong urges to continue.

During the editorial review process, our top editors ensure that we’ve covered the most essential information with compassion, clarity, and transparency. All final drafts are reviewed closely by experts in the medical field who use their personal breadth of knowledge and experience in the medical field to ensure accuracy. is a free resource for people living with substance abuse, addiction, and/or mental health disorders. While some studies define success by abstinence from AMPH/MA, others consider a reduction in use to be a measure of treatment success.

Despite the differences in experimental design, of the 27 studies on CM effectiveness in MUD, only one found that CM did not effectively reduce METH use [81]. Nevertheless, there is evidence for CM decreasing METH use months post-treatment [88]. Papers needed to be published either in English or have a published abstract in English. Persian was selected as another language for the inclusion of the abstracts and papers in this study, especially for searching in Iranian journals databases. Randomised clinical or controlled trials (RCTs) were selected if they were related to one of the study aims. Any type of pharmacological treatment for an amphetamine problem was acceptable for study inclusion.

Amphetamine Addiction Treatment

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After the initial rush, there is typically a state of high agitation that in some individuals may lead to violent behavior. A person can recover from drug misuse or SUD and improve their relationships, professional life, sense of self, and physical and mental health. A person may take years to be able to manage without the substance, and they may return to using a substance for some periods of time.

They include contingency management (CM), cognitive-behavioral therapy (CBT), the Matrix Model, 12-step facilitation therapy, the mobile medical application reSET®, and other behavioral interventions. Several systematic reviews provide detailed information on the design and the results from human studies on the efficacy of behavioral therapies in MUD [74-77]. The treatments with the most supporting evidence of effectiveness in MUD are presented below.

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